We all know about quarterback Derek Carr being out for two to six weeks with a transverse process fracture in his back and that rookie cornerback Gareon Conley is still working through a shin injury. But right guard Gabe Jackson sitting out practice with a foot issue on Wednesday was a surprise, as was defensive end Mario Edwards Jr. missing with a back injury. Jackson worked in a rehab pool with Carr on Wednesday, and Edwards has had an issue with injuries in his brief career. Some good news? Receiver Michael Crabtree returned to practice after missing last week’s loss at Denver with a chest injury. — Paul Gutierrez

Our NFL Insiders predict Week 5’s biggest upsets and fantasy flops and sleepers. Plus: Should you buy the Bills or Rams as legit playoff contenders? Which 0-4 team will get its first win? And what’s with the AFC South?

Matt Bowen, NFL writer: Texans over Chiefs. The script shouldn’t change much with quarterback Deshaun Watson and that Houston game plan. Throw the quick game, use play-pass concepts and feed the ball to DeAndre Hopkins. And the Texans can move Hopkins to multiple alignments to get the best matchups against the Chiefs secondary. But I’m also looking at Watson’s ability to make off-schedule plays. That’s key against an aggressive Kansas City defense. Get to the edge of the pocket, extend plays and attack the middle of the field. Paired with a Houston defensive front that can pressure Alex Smith, I like the Texans at home to knock off the NFL’s only undefeated squad.steelers_122